Emergency services were called to the crash at the intersection of Dyers Pass Rd and Summit Rd, near the Sign of the Kiwi just before 2pm on Saturday.
A police spokeswoman said a man was taken to Christchurch Hospital with critical injuries but died shortly after.
The road was closed shortly after the crash at the intersection of Dyers Pass Rd and Governors Bay Rd. It was set to reopened just after 7pm.
Inquiries into the circumstances of the crash were ongoing, she said.
Dyers Pass Rd has been the scene of many accidents. The road, which links Cashmere and Governors Bay, has been the scene of 170 crashes since 2008, resulting in 95 injuries and two deaths.
The previous speed limit between Summit Rd and Governors Bay Rd was 100kmh and 70kmh from just above Hackthorne Rd to Summit Rd.
Meanwhile, a cyclist crashed on the Rameka bike track near the small Tasman town of Takaka at 2.40pm on Saturday.
The cyclist was believed to be dead.
Police said more information was to come.